Model of the Human Circulatory System

The human cardiovascular system is cardinal for sustaining life: it supplies living tissue with oxygen and nutrients, and also has signalling, metabolic, and adaptive functions. Abnormalities in cardiovascular function are the main reason for many age-related diseases, the most typical of them being ischemic heart disease. The modern methods of restoring blood flow are usually invasive and carry a relatively high risk of complications, which can be partially alleviated by choosing optimal clinical decisions.

We have developed a model for the human cardiovascular system and processes related to blood circulation. Our model supports various levels of detalization and personification. By using a fully resolved 3D hydrodynamic model of blood with reduced hemodynamics models (1D and 0D, or lumped parameter), we can perform computations within time constraints, specifically, as part of a system for supporting clinical decision making.

The blood flow model is capable of assessing the consequences of local blood flow disruption, estimating the hemodynamic properties of stenosed arteries, and can also be used to study the effects of various physiological conditions, like physical exercises or g-force overload.

The function of this model is illustrated by a simulation of the human circulatory system based on a combination of one-dimensional and zero-dimensional models of hemodynamics.

Publications

  • Zun P.S., Hoekstra A.G.

    On the Possible Interaction Mechanism between Collateral Vessels and Restenosis // Procedia Computer Science. — 2015. — Vol. 66. — pp. 412-418.

Projects

  • The Russian Science Foundation #14–11–00826, 15.12.2014